Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.

Experimental gerontology - 1 Nov 2016

Molgaard Simon, Demontis Ditte, Nicholson Alexandra M, Finch Nicole A, Petersen Ronald C, Petersen Claus M, Rademakers Rosa, Nykjaer Anders, Glerup Simon

Abstract excerpt

Mutations in progranulin are a major cause of frontotemporal lobe degeneration (FTLD). Hence, plasma progranulin is an attractive biomarker in FTLD but poorly reflects levels in cerebrospinal fluid (CSF), suggesting tissue-specific regulation of progranulin levels. Sortilin was recently identified as a progranulin scavenger receptor that destines it for lysosomal degradation. Proteolysis or alternative splicing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Denmark

Share to Frontotemporal Lobar Degeneration

Share to Intercellular Signaling Peptides and Proteins

Share to Linear Models

Share to Progranulins

Source

Identifiers

PMID: 27612602
DOI: 10.1016/j.exger.2016.09.002

Genes

SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.PMID 27612602Read ↗

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.Semantic proximity Read ↗

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, ProgranulinSemantic proximity Read ↗

Potential mechanisms of progranulin-deficient FTLD.Semantic proximity Read ↗

Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia.Semantic proximity Read ↗

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptorSemantic proximity Read ↗

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.Semantic proximity Read ↗

Progranulin protein levels are differently regulated in plasma and CSF.Semantic proximity Read ↗

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin TraffickingSemantic proximity Read ↗

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.Semantic proximity Read ↗

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-RegulationSemantic proximity Read ↗

Clinical investigation of VES001, a novel oral small molecule sortilin receptor inhibitor, for the treatment of frontotemporal dementiaSemantic proximity Read ↗

Human genetics as a tool to identify progranulin regulators.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.