Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma.

International journal of molecular sciences - 23 Feb 2020

Kanda Tatsuo, Goto Taichiro, Hirotsu Yosuke, Masuzaki Ryota, Moriyama Mitsuhiko, Omata Masao

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), causes hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The patatin-like phospholipase-3 (PNPLA3) I148M sequence variant is one of the strongest genetic determinants of NAFLD/NASH. PNPLA3 is an independent risk factor for HCC among patients with NASH. The obesity epidemic is closely associated with the rising...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 17-Hydroxysteroid Dehydrogenases
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dysbiosis

Share to Fatty Liver

Share to Fibrosis

Share to Gastrointestinal Microbiome

Share to Lipase

Share to Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 32102237
DOI: 10.3390/ijms21041525
PMCID: PMC7073210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma.PMID 32102237Read ↗

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Nonalcoholic fatty liver disease.Semantic proximity Read ↗

Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liverSemantic proximity Read ↗

NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment OptionsSemantic proximity Read ↗

Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation.Semantic proximity Read ↗

Gut Microbiota-Related Cellular and Molecular Mechanisms in the Progression of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severitySemantic proximity Read ↗

Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-AnalysisSemantic proximity Read ↗

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk FactorsSemantic proximity Read ↗

MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read ↗

NAFLD-NASH: An Under-Recognized Epidemic.Semantic proximity Read ↗

Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and TherapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.