Molecular Dynamics Simulations Predict That rSNP Located in the HNF‑1α Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF‑4α Transcription Factor.

doi:10.3390/biom10121700

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Molecular Dynamics Simulations Predict That rSNP Located in the HNF‑1α Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF‑4α Transcription Factor.

Biomolecules - 21 Dec 2020

Španinger Eva, Potočnik Uroš, Bren Urban

Abstract excerpt

Our study aims to investigate the impact of the Maturity-onset diabetes of the young 3 disease-linked rSNP rs35126805 located in the HNF‑1α gene promotor on the binding of the transcription factor HNF‑4α and consequently on the regulation of HNF‑1α gene expression. Our focus is to calculate the change in the binding affinity of the transcription factor HNF‑4α to the DNA, caused by the regulatory single nucleotide...

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PMID: 33371430
DOI: 10.3390/biom10121700
PMCID: PMC7767403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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