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Article

Increased Hepatic Fat Content in Patients with Resistance to Thyroid Hormone Beta.

Thyroid : official journal of the American Thyroid Association - 1 Jul 2021

Chaves Carolina, Bruinstroop Eveline, Refetoff Samuel, Yen Paul M, Anselmo João

Abstract excerpt

Background: Thyroid hormone (TH) has important functions in controlling hepatic lipid metabolism. Individuals with resistance to thyroid hormone beta (RTHβ) who harbor mutations in the THRB gene experience loss-of-function of thyroid hormone receptor beta (TRβ), which is the predominant TR isoform expressed in the liver. We hypothesized that individuals with RTHβ may have increased hepatic steatosis. Methods:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33353459
DOI: 10.1089/thy.2020.0651
PMCID: PMC8290309

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