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Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

18 Dec 2020

Abstract excerpt

Abstract Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood...

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PMID: 33339817
DOI: 10.1038/s41467-020-20086-3

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