Article
Buccal Cell Micronucleus Frequency Is Significantly Elevated in Patients with Spinocerebellar Ataxia Type 2.
Archives of medical research - 1 Apr 2017
Cuello-Almarales Dany A, Almaguer-Mederos Luis E, Vázquez-Mojena Yaimé, Almaguer-Gotay Dennis, Zayas-Feria Pedro, Laffita-Mesa José M, González-Zaldívar Yanetza, Aguilera-Rodríguez Raúl, Rodríguez-Estupiñán Annelié, Velázquez-Pérez Luis
Abstract excerpt
Spinocerebellar ataxia type 2 (SCA2) is part of a group of at least nine dominantly inherited disorders characterized by progressive degeneration of specific neuronal populations and a shared mutational mechanism involving the expansion of a CAG repeat tract in coding regions of novel genes. Efforts have been made to identify biomarkers of disease progression, which would allow timely preventive therapeutic...
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