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Article

Mutant erythropoietin without erythropoietic activity is neuroprotective against ischemic brain injury.

Stroke - 1 Nov 2012

Gan Yu, Xing Juan, Jing Zheng, Stetler R Anne, Zhang Feng, Luo Yumin, Ji Xunming, Gao Yanqin, Cao Guodong

Abstract excerpt

BACKGROUND AND PURPOSE: Erythropoietin (EPO) confers potent neuroprotection against ischemic injury. However, treatment for stroke requires high doses and multiple administrations of EPO, which may cause deleterious side effects due to its erythropoietic activity. This study identifies a novel nonerythropoietic mutant EPO and investigates its potential neuroprotective effects and underlying mechanism in an animal...

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Source

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Identifiers

PMID: 22984011
DOI: 10.1161/STROKEAHA.112.663120
PMCID: PMC3479346

Genes

EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutant erythropoietin without erythropoietic activity is neuroprotective against ischemic brain injury.PMID 22984011Read ↗

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