Article
Successful expansion of Mycobacterium tuberculosis Latin American and Mediterranean sublineage (L4.3/LAM) in Tunisia mainly driven by a single, long-established clonal complex.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Feb 2021
Skhairia Mohamed Amine, Dekhil Naira, Mhenni Besma, Fradj Saloua Ben, Mardassi Helmi
Abstract excerpt
OBJECTIVES: To explore the evolutionary history of Mycobacterium tuberculosis Latin American and Mediterranean (L4.3/LAM) sublineage in Tunisia, where it predominates. METHODS: High-resolution genotyping of 252 L4.3/LAM clinical strains was undertaken, and whole-genome sequencing was performed on 31 representative isolates. RESULTS: Genotyping data coupled with Bayesian analyses split the Tunisian L4.3/LAM strain...
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