Article
Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney Disease.
Kidney360 - 1 Jul 2020
Grau Laura, Gitomer Berenice, McNair Bryan, Wolf Myles, Harris Peter, Brosnahan Godela, Torres Vicente, Steinman Theodore, Yu Alan, Chapman Arlene, Chonchol Michel, Nowak Kristen L
Abstract excerpt
BACKGROUND: Higher serum intact fibroblast growth factor 23 (iFGF23) was associated with disease progression in participants with autosomal dominant polycystic kidney disease (ADPKD) in the HALT-PKD Studies. PKD mutation is also an important determinant of progression. We hypothesized that serum levels of iFGF23 and vitamin D metabolites (1,25-dihydroxyvitamin D [1,25(OH)2D] and 25-hydroxyvitamin D [25[OH]D])...
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