Article
Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores.
The Journal of infectious diseases - 15 Jun 2021
Dietrich Léna G, Thorball Christian W, Ryom Lene, Burkhalter Felix, Hasse Barbara, Thurnheer Maria Christine, Weisser Maja, Schmid Patrick, Bernasconi Enos, Darling Kathrine E A, Buvelot Hélène, Fellay Jacques, Ledergerber Bruno, Tarr Philip E
Abstract excerpt
BACKGROUND: In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m2 per year for ≥3 consecutive years). METHODS: We obtained univariable and multivariable hazard ratios (HR) for rapid progression, based on the clinical D:A:D chronic kidney disease...
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