Article
An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2011
Johansen Christopher T, Wang Jian, Lanktree Matthew B, McIntyre Adam D, Ban Matthew R, Martins Rebecca A, Kennedy Brooke A, Hassell Reina G, Visser Maartje E, Schwartz Stephen M, Voight Benjamin F, Elosua Roberto, Salomaa Veikko, O'Donnell Christopher J, Dallinga-Thie Geesje M, Anand Sonia S, Yusuf Salim, Huff Murray W, Kathiresan Sekar, Cao Henian, Hegele Robert A
Abstract excerpt
OBJECTIVE: Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity....
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