Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nucleotide polymorphism in an IgA1 protease gene determines Streptococcus pneumoniae adaptation to the middle ear during otitis media.

Pathogens and disease - 9 Jan 2021

Tikhomirova Alexandra, Trappetti Claudia, Paton James C, Watson-Haigh Nathan, Wabnitz David, Jervis-Bardy Jake, Jardeleza Camille, Kidd Stephen P

Abstract excerpt

Factors facilitating the chronicity of otitis media (OM) in children are, to date, not fully understood. An understanding of molecular factors aiding bacterial persistence within the middle ear during OM could reveal pathways required for disease. This study performed a detailed analysis of Streptococcus pneumoniae populations isolated from the nasopharynx and middle ear of one OM case. Isolates were assessed for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Chronic Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ear, Middle

Share to Nasopharynx

Share to Otitis Media

Share to Pneumococcal Infections

Share to Serine Endopeptidases

Share to Streptococcus pneumoniae

Source

Identifiers

PMID: 33301554
DOI: 10.1093/femspd/ftaa077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nucleotide polymorphism in an IgA1 protease gene determines Streptococcus pneumoniae adaptation to the middle ear during otitis media.PMID 33301554Read ↗

A clonal group of nontypeable Haemophilus influenzae with two IgA proteases is adapted to infection in chronic obstructive pulmonary disease.Semantic proximity Read ↗

Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population.Semantic proximity Read ↗

IgA1 protease contributes to the virulence of Streptococcus suisSemantic proximity Read ↗

Identification of colonisation and virulence determinants of <i>Streptococcus pneumoniae</i> via experimental evolution in mouse infection modelsSemantic proximity Read ↗

Evolution and Otitis Media: A Review, and a Model to Explain High Prevalence in Indigenous PopulationsSemantic proximity Read ↗

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.Semantic proximity Read ↗

Streptococcus pneumoniae Strains Isolated From a Single Pediatric Patient Display Distinct Phenotypes.Semantic proximity Read ↗

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].Semantic proximity Read ↗

Epidemiology and pathogenesis of otitis media: construction of a phenotype landscape.Semantic proximity Read ↗

Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniaeSemantic proximity Read ↗

Differential occurrence of Streptococcus pneumoniae serotype 11E between asymptomatic carriage and invasive pneumococcal disease isolates reflects a unique model of pathogen microevolution.Semantic proximity Read ↗

Contemporary Pharyngeal and Invasive emm1 and Invasive emm12 Group A Streptococcus Isolates Exhibit Similar In Vivo Selection for CovRS Mutants in Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.