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On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer

13 Nov 2020

Abstract excerpt

We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of FOLFOX. Surprisingly, we did not observe a spike in ctDNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or...

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PMID: 33299124
DOI: 10.1038/s41698-020-00134-3

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