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Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

8 Apr 2014

Abstract excerpt

BACKGROUND: Hypermethylation of DNA is an epigenetic alteration commonly found in colorectal cancer (CRC) and can also be detected in blood samples of cancer patients. Methylation of the genes helicase-like transcription factor (HLTF) and hyperplastic polyposis 1 (HPP1) have been proposed as prognostic, and neurogenin 1 (NEUROG1) as diagnostic biomarker. However the underlying mechanisms leading to the release of...

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PMID: 24708595
DOI: 10.1186/1471-2407-14-245

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