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Article

Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment.

Microbial cell factories - 9 Dec 2020

Qiao Wanjin, Qiao Yu, Liu Fulu, Zhang Yating, Li Ran, Wu Zhenzhou, Xu Haijin, Saris Per Erik Joakim, Qiao Mingqiang

Abstract excerpt

BACKGROUND: In bioengineering, growth of microorganisms is limited because of environmental and industrial stresses during fermentation. This study aimed to construct a nisin-producing chassis Lactococcus lactis strain with genome-streamlined, low metabolic burden, and multi-stress tolerance characteristics. RESULTS: The Cre-loxP recombination system was applied to reduce the genome and obtain the target chassis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33298073
DOI: 10.1186/s12934-020-01487-x
PMCID: PMC7727215

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