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Article

Nanopore sequencing sheds a light on the FLT3 gene mutations complexity in acute promyelocytic leukemia.

Leukemia & lymphoma - 1 May 2021

Cumbo Cosimo, Orsini Paola, Anelli Luisa, Zagaria Antonella, Minervini Crescenzio Francesco, Coccaro Nicoletta, Tota Giuseppina, Impera Luciana, Parciante Elisa, Conserva Maria Rosa, Redavid Immacolata, Carluccio Paola, Tarantini Francesco, Specchia Giorgina, Musto Pellegrino, Albano Francesco

Abstract excerpt

Acute promyelocytic leukemia (APL) patients carry in 27% of cases an activating mutation of the fms-like tyrosine kinase-3 (FLT3) gene: internal tandem duplication (ITD) or tyrosine kinase domain (TKD) point mutation. The simultaneous presence of both types of mutations, so-called FLT3 dual mutations, has been reported in 2% of APL, but this circumstance has never been studied. We studied a cohort of 74 APL...

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Identifiers

PMID: 33289421
DOI: 10.1080/10428194.2020.1856838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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