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Article

Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome.

Critical care (London, England) - 7 Dec 2020

Yehya Nadir, Varisco Brian M, Thomas Neal J, Wong Hector R, Christie Jason D, Feng Rui

Abstract excerpt

BACKGROUND: Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify subtypes of pediatric ARDS based on whole blood transcriptomics. METHODS: This was a prospective observational study of children with ARDS at the Children's Hospital of Philadelphia (CHOP) between January 2018 and June 2019. We collected blood within...

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Identifiers

PMID: 33287889
DOI: 10.1186/s13054-020-03410-7
PMCID: PMC7720038

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