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Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain.

Viruses - 16 May 2020

Anwar Muhammad Naveed, Wang Xin, Hameed Muddassar, Wahaab Abdul, Li Chenxi, Sharma Mona, Pang Linlin, Malik Muhammad Irfan, Liu Ke, Li Beibei, Qiu Yafeng, Wei Jianchao, Ma Zhiyong

Abstract excerpt

The phenotypic and genotypic characteristics of a live-attenuated genotype I (GI) strain (SD12-F120) of Japanese encephalitis virus (JEV) were compared with its virulent parental SD12 strain to gain an insight into the genetic changes acquired during the attenuation process. SD12-F120 formed smaller plaque on BHK-21 cells and showed reduced replication in mouse brains compared with SD12. Mice inoculated with...

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Identifiers

PMID: 32429445
DOI: 10.3390/v12050552
PMCID: PMC7290960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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