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Article

The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis‐Mediated Innate Immune Response

1 Jan 2020

Abstract excerpt

The sirtuins (SIRTs), including seven family members, belong to class III histone deacetylase (HDAC) enzymes, which have been intensively investigated in cancers. Although the function of SIRTs in the cancer immunology is explored, SIRT‐specific mechanisms regulating necroptosis‐related innate immune response are not clear. In our present study, we found that both the mRNA and protein expression levels of SIRT3...

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PMID: 33282964
DOI: 10.1155/2020/8820355

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