Article
Finding a suitable library size to call variants in RNA-Seq.
BMC bioinformatics - 1 Dec 2020
Quaglieri Anna, Flensburg Christoffer, Speed Terence P, Majewski Ian J
Abstract excerpt
BACKGROUND: RNA sequencing allows the study of both gene expression changes and transcribed mutations, providing a highly effective way to gain insight into cancer biology. When planning the sequencing of a large cohort of samples, library size is a fundamental factor affecting both the overall cost and the quality of the results. Here we specifically address how overall library size influences the detection of...
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