Article
Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity.
International journal of molecular sciences - 27 Nov 2020
Chiurazzi Martina, Cozzolino Mauro, Orsini Roberta Clara, Di Maro Martina, Di Minno Matteo Nicola Dario, Colantuoni Antonio
Abstract excerpt
Rare genetic obesity disorders are characterized by mutations of genes strongly involved in the central or peripheral regulation of energy balance. These mutations are effective in causing the early onset of severe obesity and insatiable hunger (hyperphagia), suggesting that the genetic component can contribute to 40-70% of obesity. However, genes' roles in the processes leading to obesity are still unclear. This...
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