Genetic determinants of obesity: mechanisms, clinical implications, and targeted therapies.

doi:10.1007/s12020-026-04696-3

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Article

Genetic determinants of obesity: mechanisms, clinical implications, and targeted therapies.

Endocrine - 13 Jul 2026

Serbis Anastasios, Kantza Evanthia, Garoufou Michaela, Christou Maria, Siomou Ekaterini, Tigas Stelios

Abstract excerpt

PURPOSE: Obesity is a major global health crisis with rising prevalence in both pediatric and adult populations, leading to an increased risk of cardiovascular, metabolic, and other chronic complications affecting all organ systems. A clear understanding of the genetic contributors to polygenic, syndromic, and monogenic obesity is essential for early diagnosis and targeted management. METHODS: Advances in...

Topics

Humans
Obesity
Genetic Predisposition to Disease
Genome-Wide Association Study

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Open in PubMed Open full text

Identifiers

PMID: 42440185
DOI: 10.1007/s12020-026-04696-3
PMCID: PMC13364813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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