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BRAF Targeting Across Solid Tumors: Molecular Aspects and Clinical Applications

16 Apr 2025

Abstract excerpt

, is a key therapeutic target. Targeted treatments with BRAF and MEK inhibitors have significantly improved progression-free and overall survival in melanoma patients. However, in cancers like metastatic colorectal cancer, BRAF mutations are associated with poor outcomes due to aggressive disease behavior and resistance to conventional chemotherapy. Despite progress, resistance to BRAF/MEK inhibitors remains a...

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PMID: 40332392
DOI: 10.3390/ijms26083757

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