Article
A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity.
Marine drugs - 29 Nov 2020
Gallo Carmela, Barra Giusi, Saponaro Marisa, Manzo Emiliano, Fioretto Laura, Ziaco Marcello, Nuzzo Genoveffa, d'Ippolito Giuliana, De Palma Raffaele, Fontana Angelo
Abstract excerpt
Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for the preclinical discovery of anticancer candidates. The platform relies on the use of dendritic...
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