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Article

TERT promoter alterations could provide a solution for Peto's paradox in rodents.

Scientific reports - 30 Nov 2020

Vedelek Balázs, Maddali Asha Kiran, Davenova Nurgul, Vedelek Viktor, Boros Imre M

Abstract excerpt

Cancer is a genetic disease caused by changes in gene expression resulting from somatic mutations and epigenetic changes. Although the probability of mutations is proportional with cell number and replication cycles, large bodied species do not develop cancer more frequently than smaller ones. This notion is known as Peto's paradox, and assumes stronger tumor suppression in larger animals. One of the possible...

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PMID: 33257697
DOI: 10.1038/s41598-020-77648-0
PMCID: PMC7704627

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