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Evolution of telomere maintenance and tumour suppressor mechanisms across mammals

15 Jan 2018

Abstract excerpt

Mammalian species differ dramatically in telomere biology. Species larger than 5-10 kg repress somatic telomerase activity and have shorter telomeres, leading to replicative senescence. It has been proposed that evolution of replicative senescence in large-bodied species is an anti-tumour mechanism counteracting increased risk of cancer due to increased cell numbers. By contrast, small-bodied species express high...

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Share to Animal Genetics and Reproduction
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PMID: 29335367
DOI: 10.1098/rstb.2016.0443

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