Article
Correlation of CLEC1B haplotypes with plasma levels of soluble CLEC-2 in healthy individuals.
Platelets - 17 Nov 2021
Etemad Mani, Christodoulou Foteini, Weiss Christel, Klüter Harald, Bugert Peter
Abstract excerpt
Binding of podoplanin to the C-type lectin-like receptor 2 (CLEC-2) promotes platelet activation and soluble CLEC-2 (sCLEC-2) is shed from activated platelets. The role of sCLEC-2 in the plasma is unknown. The expression level and plasma concentration of sCLEC-2 could be affected by variants of the corresponding gene, CLEC1B. Here, we genotyped SNVs in the promoter and coding region of CLEC1B and determined...
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