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Article

Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype.

Osteoarthritis and cartilage - 1 Feb 2021

Reed K S M, Ulici V, Kim C, Chubinskaya S, Loeser R F, Phanstiel D H

Abstract excerpt

OBJECTIVE: Fibronectin is a matrix protein that is fragmented during cartilage degradation in osteoarthritis (OA). Treatment of chondrocytes with fibronectin fragments (FN-f) has been used to model OA in vitro, but the system has not been fully characterized. This study sought to define the transcriptional response of chondrocytes to FN-f, and directly compare it to responses traditionally observed in OA. DESIGN:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33248223
DOI: 10.1016/j.joca.2020.09.006
PMCID: PMC7870543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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