Article
Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2017
Levitt Roy C, Zhuang Gerald Y, Kang Yuan, Erasso Diana M, Upadhyay Udita, Ozdemir Mehtap, Fu Eugene S, Sarantopoulos Konstantinos D, Smith Shad B, Maixner William, Diatchenko Luda, Martin Eden R, Wiltshire Tim
Abstract excerpt
Carbonic anhydrase-8 (Car8 mouse gene symbol) is devoid of enzymatic activity, but instead functions as an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1) to regulate this intracellular calcium release channel important in synaptic functions and neuronal excitability. Causative mutations in ITPR1 and carbonic anhydrase-8 in mice and humans are associated with certain subtypes of spinal...
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