Article
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021
Al Khazal Fatimah, Kang Seungwoo, Nelson Holte Molly, Choi Doo-Sup, Singh Ravinder, Ortega-Sáenz Patricia, López-Barneo José, Maher L James
Abstract excerpt
Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound enzyme complex that is involved in both the tricarboxylic acid cycle and the electron transport chain, can lead to a variety of disorders. Recognized conditions with such mutations include Leigh syndrome and hereditary tumors such as pheochromocytoma and paraganglioma (PPGL), renal cell...
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