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Article

The presence of TIM-3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status.

Brain pathology (Zurich, Switzerland) - 1 May 2021

Sørensen Mia D, Nielsen Ole, Reifenberger Guido, Kristensen Bjarne W

Abstract excerpt

Diffuse gliomas are aggressive brain tumors that respond poorly to immunotherapy including immune checkpoint inhibition. This resistance may arise from an immunocompromised microenvironment and deficient immune recognition of tumor cells because of low mutational burden. The most prominent genetic alterations in diffuse glioma are mutations in the isocitrate dehydrogenase (IDH) genes that generate the...

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Identifiers

PMID: 33244787
DOI: 10.1111/bpa.12921
PMCID: PMC8412096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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