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Article

Association of a diffuse phenotype on MRI with shorter overall survival in patients with astrocytoma CNS WHO grades 2 and 3.

Journal of neurosurgery - 1 Jun 2026

Weller Jonathan, Harba Dima, Kuschel Luis, Thiele Frederic, Katzendobler Sophie, Corell Alba, Dénes Anna, Schmutzer-Sondergeld Michael, de Dios Eddie, Ringel Florian, Tonn Joerg Christian, Jakola Asgeir S

Abstract excerpt

OBJECTIVE: Gliomas can appear radiologically diffuse or sharply delineated on MRI. This can be quantified by the T1/T2 ratio, a quotient of the T1 hypointense to T2 hyperintense tumor volume. In patients with CNS WHO grade 2 and 3 isocitrate dehydrogenase (IDH)-mutant astrocytomas, resectability has been shown to be limited in cases of low T1/T2 ratios, that is, in diffusely appearing astrocytomas. The authors...

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PMID: 41616295
DOI: 10.3171/2025.9.JNS251254

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