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Article

No signs of subclinical atherosclerosis after risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers.

Journal of cardiology - 1 Jun 2021

van Bommel Majke H D, de Jong Marieke Arts, Steenbeek Miranda P, Bots Michiel L, van Westerop Liselore L M, Hopman Maria T E, Hoogerbrugge Nicoline, de Hullu Joanne A, Maas Angela H E M

Abstract excerpt

BACKGROUND: BRCA1/2 mutation carriers are generally exposed to early menopause due to risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 years. This risk-reducing intervention is based on a 10-40% life-time risk of ovarian cancer in this population. Although effective, premature and acute menopause induces non-cancer related morbidity in both the short and long term. Little is known about the impact...

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Identifiers

PMID: 33229237
DOI: 10.1016/j.jjcc.2020.11.005

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