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Article

Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes.

Acta neuropathologica communications - 23 Nov 2020

Takadera Mutsumi, Satomi Kaishi, Szulzewsky Frank, Cimino Patrick J, Holland Eric C, Yamamoto Tetsuya, Ichimura Koichi, Ozawa Tatsuya

Abstract excerpt

Recurrent RELA and YAP1 fusions are intimately associated with tumorigenesis in supratentorial ependymomas. Chromothripsis and focal copy number alterations involving 11q are hallmarks of these tumors. However, it is unknown whether the chromosomal alterations are a direct causal event resulting in fusion transcripts. In addition, the biological significance of the RELA fusion variants and YAP1 fusions is not yet...

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Source

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Identifiers

PMID: 33228790
DOI: 10.1186/s40478-020-01080-8
PMCID: PMC7684901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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