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Article

Candidate Gene Discovery in Hereditary Colorectal Cancer and Polyposis Syndromes-Considerations for Future Studies.

International journal of molecular sciences - 19 Nov 2020

Te Paske Iris B A W, Ligtenberg Marjolijn J L, Hoogerbrugge Nicoline, de Voer Richarda M

Abstract excerpt

To discover novel high-penetrant risk loci for hereditary colorectal cancer (hCRC) and polyposis syndromes many whole-exome and whole-genome sequencing (WES/WGS) studies have been performed. Remarkably, these studies resulted in only a few novel high-penetrant risk genes. Given this observation, the possibility and strategy to identify high-penetrant risk genes for hCRC and polyposis needs reconsideration....

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Identifiers

PMID: 33228212
DOI: 10.3390/ijms21228757
PMCID: PMC7699508

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