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Article

Disease duration in autosomal dominant familial Alzheimer disease

19 Aug 2020

Abstract excerpt

Objective To use survival modeling to estimate disease duration in autosomal dominant familial Alzheimer disease (ADAD) and ascertain whether factors influencing age at onset also affect survival. Methods Symptomatic mutation carriers (201 presenilin 1 [PSEN1] and 55 amyloid precursor protein [APP]) from ADAD families referred to the Dementia Research Centre, between 1987 and 2019, were included. Survival was...

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PMID: 33225064
DOI: 10.1212/nxg.0000000000000507

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