Article
A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
Journal of autoimmunity - 1 Jan 2021
Alborzian Deh Sheikh Amin, Gomaa Soha, Li Xuexin, Routledge Matthew, Saigoh Kazumasa, Numoto Nobutaka, Angata Takashi, Hitomi Yuki, Takematsu Hiromu, Tsuiji Makoto, Ito Nobutoshi, Kusunoki Susumu, Tsubata Takeshi
Abstract excerpt
Guillain-Barré syndrome (GBS), including its variant Miller Fisher syndrome (MFS), is an acute peripheral neuropathy that involves autoimmune mechanisms leading to the production of autoantibodies to gangliosides; sialic acid-containing glycosphingolipids. Although association with various genetic polymorphisms in the major histocompatibility complex (MHC) is shown in other autoimmune diseases, GBS is an...
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