Article
SCN5A mutation in Brugada syndrome is associated with substrate severity detected by electrocardiographic imaging and high-density electroanatomic mapping.
Heart rhythm - 1 Jun 2022
Pannone Luigi, Monaco Cinzia, Sorgente Antonio, Vergara Pasquale, Gauthey Anaïs, Calburean Paul-Adrian, Bisignani Antonio, Paparella Gaetano, Ramak Robbert, Overeinder Ingrid, Bala Gezim, Almorad Alexandre, Ströker Erwin, Pappaert Gudrun, Sieira Juan, Brugada Pedro, Van Dooren Sonia, de Ravel Thomy, La Meir Mark, Chierchia Gian Battista, de Asmundis Carlo
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS) is caused by mutations in SCN5A gene in 15%-20% of cases. Previous studies showed worse prognosis in SCN5A mutation carriers (SCN5A+). To date, there are no data on genotype-phenotype correlation with electrocardiographic (ECG) imaging (ECGI) and high-density epicardial electroanatomic map. OBJECTIVE: This study aimed to correlate SCN5A mutation with substrate severity in BrS...
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