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Mutation profile differences in younger and older patients with advanced breast cancer using circulating tumor DNA (ctDNA).

Breast cancer research and treatment - 1 Feb 2021

Clifton Katherine, Luo Jingqin, Tao Yu, Saam Jennifer, Rich Thereasa, Roshal Anna, Frith Ashley, Rigden Caron, Ademuyiwa Foluso, Weilbaecher Katherine, Hernandez-Aya Leonel, Peterson Lindsay L, Bagegni Nusayba, Suresh Rama, Bose Ron, Opyrchal Mateusz, Wildes Tanya M, Ma Cynthia

Abstract excerpt

PURPOSE: Little is known regarding the mutation profiles of ctDNA in the older adult breast cancer population. The objective of this study is to assess differences in mutation profiles in the older adult breast cancer population using a ctDNA assay as well as assess utilization of testing results. METHODS: Patients with advanced breast cancer underwent molecular profiling using a plasma-based ctDNA NGS assay...

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Source

Identifiers

PMID: 33219484
DOI: 10.1007/s10549-020-06019-0

Genes

ATM
PIK3CA
BRAF
GATA3
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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