Article
Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments.
Physical review. E - 1 Oct 2020
Ardaševa Aleksandra, Anderson Alexander R A, Gatenby Robert A, Byrne Helen M, Maini Philip K, Lorenzi Tommaso
Abstract excerpt
Deterministic continuum models formulated as nonlocal partial differential equations for the evolutionary dynamics of populations structured by phenotypic traits have been used recently to address open questions concerning the adaptation of asexual species to periodically fluctuating environmental conditions. These models are usually defined on the basis of population-scale phenomenological assumptions and cannot...
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