Article
Somatic mutational landscapes of adherens junctions and their functional consequences in cutaneous melanoma development.
Theranostics - 1 Jan 2020
Korla Praveen Kumar, Chen Chih-Chieh, Gracilla Daniel Esguerra, Lai Ming-Tsung, Chen Chih-Mei, Chen Huan Yuan, Hwang Tritium, Chen Shih-Yin, Sheu Jim Jinn-Chyuan
Abstract excerpt
Cell-cell interaction in skin homeostasis is tightly controlled by adherens junctions (AJs). Alterations in such regulation lead to melanoma development. However, mutations in AJs and their functional consequences are still largely unknown. Methods: Cadherin mutations in skin cutaneous melanoma were identified using sequencing data from TCGA dataset, followed by cross-validation with data from non-TCGA cohorts....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.