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Article

TRIB3 facilitates glioblastoma progression via restraining autophagy

16 Nov 2020

Abstract excerpt

, while knockdown of TRIB3 expression exerted a repressive effect on these cellular processes. The growth-promoting effect of TRIB3 was also demonstrated in a xenograft mouse model. Mechanistic studies further revealed that TRIB3 was able to suppress autophagic flux and that this suppression was responsible for TRIB3 silencing-induced proliferation and migration of GBM cells. These findings indicate that the...

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PMID: 33203798
DOI: 10.18632/aging.103969

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