Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

doi:10.2337/dc20-1328

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Article

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

Diabetes care - 1 Jan 2021

Zheng Ju-Sheng, Luan Jian'an, Sofianopoulou Eleni, Imamura Fumiaki, Stewart Isobel D, Day Felix R, Pietzner Maik, Wheeler Eleanor, Lotta Luca A, Gundersen Thomas E, Amiano Pilar, Ardanaz Eva, Chirlaque María-Dolores, Fagherazzi Guy, Franks Paul W, Kaaks Rudolf, Laouali Nasser, Mancini Francesca Romana, Nilsson Peter M, Onland-Moret N Charlotte, Olsen Anja, Overvad Kim, Panico Salvatore, Palli Domenico, Ricceri Fulvio, Rolandsson Olov, Spijkerman Annemieke M W, Sánchez María-José, Schulze Matthias B, Sala Núria, Sieri Sabina, Tjønneland Anne, Tumino Rosario, van der Schouw Yvonne T, Weiderpass Elisabete, Riboli Elio, Danesh John, Butterworth Adam S, Sharp Stephen J, Langenberg Claudia, Forouhi Nita G, Wareham Nicholas J

Abstract excerpt

OBJECTIVE: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. RESEARCH DESIGN AND METHODS: We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel...

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Identifiers

PMID: 33203707
DOI: 10.2337/dc20-1328
PMCID: PMC7783939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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