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Article

Evidence for dynamic in vivo interconversion of the conformational states of IscU during iron-sulfur cluster biosynthesis.

Molecular microbiology - 1 Apr 2021

Sato Sakiko, Matsushima Yumeka, Kanazawa Miaki, Tanaka Naoyuki, Fujishiro Takashi, Kunichika Kouhei, Nakamura Ryosuke, Tomioka Hiroaki, Wada Kei, Takahashi Yasuhiro

Abstract excerpt

IscU is a central component of the ISC machinery and serves as a scaffold for de novo assembly of Fe-S clusters. The dedicated chaperone system composed of the Hsp70-chaperone HscA and the J-protein cochaperone HscB synergistically interacts with IscU and facilitates cluster transfer from IscU to recipient apo-proteins. Here, we report that the otherwise essential roles of HscA and HscB can be bypassed in vivo by...

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PMID: 33202070
DOI: 10.1111/mmi.14646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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