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Article

Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU.

The Journal of biological chemistry - 26 Jul 2002

Hoff Kevin G, Ta Dennis T, Tapley Tim L, Silberg Jonathan J, Vickery Larry E

Abstract excerpt

Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by which Hsc66 selectively binds IscU is unknown. We have investigated Hsc66 substrate specificity using phage display and a peptide array of IscU. Screening of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11994302
DOI: 10.1074/jbc.M202814200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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