Article
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms.
Frontiers in endocrinology - 1 Jan 2020
Keindl Magdalena, Fedotkina Olena, du Plessis Elsa, Jain Ruchi, Bergum Brith, Mygind Jensen Troels, Laustrup Møller Cathrine, Falhammar Henrik, Nyström Thomas, Catrina Sergiu-Bogdan, Jörneskog Gun, Groop Leif, Eliasson Mats, Eliasson Björn, Brismar Kerstin, Nilsson Peter M, Berg Tore Julsrud, Appel Silke, Lyssenko Valeriya
Abstract excerpt
Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who do not progress...
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