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Article

Single nucleotide variants c.-13G → C (rs17429833) and c.108C → T (rs72466472) in the CLDN1 gene and increased risk for familial colorectal cancer.

Gene - 5 Feb 2021

Battagin André Silva, Bertuzzo Carmen Sílvia, Carvalho Patrícia Oliveira, Ortega Manoela Marques, Marson Fernando Augusto Lima

Abstract excerpt

BACKGROUND: The Claudin-1 (CLDN1) protein plays an important role in the function of the tight junction and studies have shown it is aberrantly downregulated in many tumors including colorectal cancer (CRC). The aim of this study was to determine the relationship between four SNVs in the CLDN1 gene [c.-13G → C (rs17429833), c.108C → T (rs72466472), c.369T → C (rs9869263), and c.370G → A (rs140846629)] and the...

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Identifiers

PMID: 33186612
DOI: 10.1016/j.gene.2020.145304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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