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Article

Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Thrombosis and haemostasis - 1 Apr 2021

Basu Malay Kumar, Massicano Felipe, Yu Lijia, Halkidis Konstantine, Pillai Vikram, Cao Wenjing, Zheng Liang, Zheng X Long

Abstract excerpt

BACKGROUND: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal blood disorder, resulting from autoantibodies against ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). However, the mechanism underlying anti-ADAMTS13 autoantibody formation is not known, nor it is known how genetic aberrations contribute to the pathogenesis of iTTP. METHODS:...

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Identifiers

PMID: 33184803
DOI: 10.1055/s-0040-1719030
PMCID: PMC8091491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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