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Article

Functional Outcomes Across High-Risk OCT-Based Phenotypes in Intermediate Age-Related Macular Degeneration-PINNACLE Study Report 11.

Investigative ophthalmology & visual science - 1 Dec 2025

Enzendorfer Marie Louise, Mai Julia, Riedl Sophie, Bogunovic Hrvoje, Menten Martin J, Rueckert Daniel, Fritsche Lars G, Prevost A Toby, Sivaprasad Sobha, Pfau Maximilian, Scholl Hendrik P N, Lotery Andrew J, Sacu Stefan, Schmidt-Erfurth Ursula

Abstract excerpt

Purpose: To evaluate the association between structural optical coherence tomography (OCT) biomarkers and functional outcomes in intermediate age-related macular degeneration (iAMD) and to investigate whether stratifying eyes by OCT-based biomarkers identifies phenotypes of iAMD with impaired visual function. Methods: The baseline cohort of the PINNACLE trial underwent OCT imaging, microperimetry, best-corrected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41405094
DOI: 10.1167/iovs.66.15.54
PMCID: PMC12716453

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