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Article

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

PloS one - 18 Feb 2010

Langendorf Christopher G, Key Trevor L G, Fenalti Gustavo, Kan Wan-Ting, Buckle Ashley M, Caradoc-Davies Tom, Tuck Kellie L, Law Ruby H P, Whisstock James C

Abstract excerpt

BACKGROUND: In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated levels of GABA and gamma-Hydroxybutyric acid (GHB...

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Identifiers

PMID: 20174634
DOI: 10.1371/journal.pone.0009280
PMCID: PMC2823781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20174634-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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